Infobox drug development (Drugbox - talk central , overview, sandboxes, testcases) WT:PHARM
Infobox drug (/sbox edit diff /test | Source e Talk hist links # /subpages /doc )
/testcases2 -- titles, licence, EMA/testcases3 -- pregcat, legal, licence, PLLR, ATC; Wikidata/testcases4 -- chem formula, mab/testcases5 -- identifiers, second id's/testcases6 -- all up/testcases7images -- images/testcases8 -- type, titles/testcases9 -- order variants, container_only/testcases10 -- pharmacokinetic, localINN (2017) has (data page) -- is a redirect/testcases11 -- hormone, gene therapy (2018) , has (data page)/testcases-FDA -- FDA 2023/testcases-warning -- warning box(es)
විරේචනය PID |PubChem=3007
විරේචනය SID |PubChem=7003 (?)
විරේචනය FA
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Amfetamine Pronunciation i / æ m ˈ f ɛ t ə m iː n / Trade names Adderall, Dyanavel XR, Evekeo, others Other names α-methylphenethylamine AHFS /Drugs.com amphetamine License data
Dependence Physical : nonePsychological : moderateAddiction Moderate Routes of Medical: oral (ingestion) , nasal inhalation , intravenous oral , nasal inhalation , insufflation , rectal , intravenous ATC code Legal status
Bioavailability Oral 75–100% Protein binding 15–40% Metabolism Amphetamine only:CYP2D6 , DBH , FMO3 Metabolites 4-hydroxyamphetamine 4-hydroxynorephedrine 4-hydroxyphenylacetone benzoic acid , hippuric acid , norephedrine , phenylacetone Onset of action IR dosing: 30–60 minutes[ 1] XR dosing: 1.5–2 hours[ 2] [ 3] Elimination half-life D-amph :9–11 hoursL-amph :11–14 hourspH -dependent: 8–31 hoursDuration of action IR dosing: 3–7 hours[ 4] XR dosing: 12 hoursExcretion Primarily renal ;pH -dependent range: 1–75%
(RS )-1-phenylpropan-2-amine
CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL NIAID ChemDB PDB ligand Formula C 9 H 13 N Molar mass 135.20622 g/mol 3D model (JSmol ) Chirality 1:1 mixture (racemate ) Density 0.9±0.1 g/cm3 Melting point 11.3 °C (52.3 °F) (predicted)[ 5] Boiling point 203 °C (397 °F) at 760 mmHg
InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
Key:KWTSXDURSIMDCE-UHFFFAOYSA-N
Amfetamine Pronunciation i / æ m ˈ f ɛ t ə m iː n / Trade names Adderall, Dyanavel XR, Evekeo, others Other names α-methylphenethylamine AHFS /Drugs.com amphetamine License data
Dependence Physical : nonePsychological : moderateAddiction Moderate Routes of Medical: oral (ingestion) , nasal inhalation , intravenous oral , nasal inhalation , insufflation , rectal , intravenous ATC code Legal status
Bioavailability Oral 75–100% Protein binding 15–40% Metabolism Amphetamine only:CYP2D6 , DBH , FMO3 Metabolites 4-hydroxyamphetamine 4-hydroxynorephedrine 4-hydroxyphenylacetone benzoic acid , hippuric acid , norephedrine , phenylacetone Onset of action IR dosing: 30–60 minutes[ 1] XR dosing: 1.5–2 hours[ 2] [ 3] Elimination half-life D-amph :9–11 hoursL-amph :11–14 hourspH -dependent: 8–31 hoursDuration of action IR dosing: 3–7 hours[ 4] XR dosing: 12 hoursExcretion Primarily renal ;pH -dependent range: 1–75%
(RS )-1-phenylpropan-2-amine
CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL NIAID ChemDB PDB ligand Formula C 9 H 13 N Molar mass 135.20622 g/mol 3D model (JSmol ) Chirality 1:1 mixture (racemate ) Density 0.9±0.1 g/cm3 Melting point 11.3 °C (52.3 °F) (predicted)[ 5] Boiling point 203 °C (397 °F) at 760 mmHg
InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
Key:KWTSXDURSIMDCE-UHFFFAOYSA-N
විරේචනය
Side by side comparison {{Infobox drug }} {{Infobox drug/sandbox }}
Aspirin Pronunciation acetylsalicylic acid / ə ˌ s iː t əl ˌ s æ l ᵻ ˈ s ɪ l ᵻ k / Other names 2-acetoxybenzoic acid AHFS /Drugs.com Monograph MedlinePlus a682878 License data
Pregnancy Routes of Most commonly oral, also rectal, lysine acetylsalicylate may be given intravenously or intramuscularly ATC code Legal status
AU :S2 (Pharmacy medicine) except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.UK :General sales list (GSL, OTC)US :OTC
Bioavailability 80–100%[ 6] Protein binding 80–90%[ 7] Metabolism Hepatic , (CYP2C19 and possibly CYP3A ), some is also hydrolysed to salicylate in the gut wall.[ 7] Elimination half-life Dose-dependent; 2–3 hours for low doses, 15–30 hours for large doses.[ 7] Excretion Urine (80–100%), sweat, saliva, feces[ 6] CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL PDB ligand Formula C 9 H 8 O 4 Molar mass 180.157 g/mol 3D model (JSmol ) Density 1.40 g/cm3 Melting point 135 °C (275 °F) Boiling point 140 °C (284 °F) (decomposes) Solubility in water 3 mg/mL (20 °C)
InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
Key:BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Aspirin Pronunciation acetylsalicylic acid / ə ˌ s iː t əl ˌ s æ l ᵻ ˈ s ɪ l ᵻ k / Other names 2-acetoxybenzoic acid AHFS /Drugs.com Monograph MedlinePlus a682878 License data
Pregnancy Routes of Most commonly oral, also rectal, lysine acetylsalicylate may be given intravenously or intramuscularly ATC code Legal status
AU :S2 (Pharmacy medicine) except when given intravenously (in which case it is schedule 4), used in animal medicine (schedule 5/6) or when the dose is higher than usual.UK :General sales list (GSL, OTC)US :OTC
Bioavailability 80–100%[ 6] Protein binding 80–90%[ 7] Metabolism Hepatic , (CYP2C19 and possibly CYP3A ), some is also hydrolysed to salicylate in the gut wall.[ 7] Elimination half-life Dose-dependent; 2–3 hours for low doses, 15–30 hours for large doses.[ 7] Excretion Urine (80–100%), sweat, saliva, feces[ 6] CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL PDB ligand Formula C 9 H 8 O 4 Molar mass 180.157 g/mol 3D model (JSmol ) Density 1.40 g/cm3 Melting point 135 °C (275 °F) Boiling point 140 °C (284 °F) (decomposes) Solubility in water 3 mg/mL (20 °C)
InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
Key:BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Side by side comparison {{Infobox drug }} {{Infobox drug/sandbox }}
Infobox drug/testcases9 Pronunciation / ˌ m ɛ θ æ m ˈ f ɛ t əm iː n / Trade names Desoxyn Other names N -methylamphetamine N ,α-dimethylphenethylamine AHFS /Drugs.com Monograph License data
Dependence Physical Psychological Addiction Very high Routes of Medical: oral (ingestion) , intravenous [ 8] oral , intravenous , intramuscular , subcutaneous , smoke inhalation , insufflation , rectal , vaginal ATC code Legal status
Bioavailability Oral: 70%[ 9] [ 9] Protein binding Varies widely[ 10] Metabolism CYP2D6 ,[ 11] DBH ,[ 12] FMO3 ,[ 13] XM-ligase ,[ 14] ACGNAT [ 15] Onset of action Rapid[ 16] Elimination half-life 5–30 hours[ 17] Duration of action 10–20 hours[ 16] Excretion Primarily renal CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Formula C 10 H 15 N Molar mass 149.24 g·mol−1 3D model (JSmol ) Chirality 1:1 mixture (racemate ) Melting point 3 °C (37 °F) (predicted)[ 5] Boiling point 212 °C (414 °F) at 760 mmHg [ 18]
InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3
Y Key:MYWUZJCMWCOHBA-UHFFFAOYSA-N
Y
Infobox drug/testcases9 Pronunciation / ˌ m ɛ θ æ m ˈ f ɛ t əm iː n / Trade names Desoxyn Other names N -methylamphetamine N ,α-dimethylphenethylamine AHFS /Drugs.com Monograph License data
Dependence Physical Psychological Addiction Very high Routes of Medical: oral (ingestion) , intravenous [ 8] oral , intravenous , intramuscular , subcutaneous , smoke inhalation , insufflation , rectal , vaginal ATC code Legal status
Bioavailability Oral: 70%[ 9] [ 9] Protein binding Varies widely[ 10] Metabolism CYP2D6 ,[ 11] DBH ,[ 12] FMO3 ,[ 13] XM-ligase ,[ 14] ACGNAT [ 15] Onset of action Rapid[ 16] Elimination half-life 5–30 hours[ 17] Duration of action 10–20 hours[ 16] Excretion Primarily renal CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Formula C 10 H 15 N Molar mass 149.24 g·mol−1 3D model (JSmol ) Chirality 1:1 mixture (racemate ) Melting point 3 °C (37 °F) (predicted)[ 5] Boiling point 212 °C (414 °F) at 760 mmHg [ 18]
InChI=1S/C10H15N/c1-9(11-2)8-10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3
Y Key:MYWUZJCMWCOHBA-UHFFFAOYSA-N
Y
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