විකිපීඩියා

සැකිල්ල:Infobox drug/testcases-warning

< සැකිල්ල:Infobox drug

Paracetamol

සංස්කරණය
Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Paracetamol
Clinical data
PronunciationParacetamol: /ˌpærəˈsiːtəmɒl/
Acetaminophen: අසන්නi/əˌsiːtəˈmɪnəfɪn/
Trade namesTylenol, Panadol, others[1]
Other namesN-acetyl-para-aminophenol (APAP), acetaminophen (USAN US)
AHFS/Drugs.comMonograph
MedlinePlusa681004
License data
Pregnancy
category
Routes of
administration		Oral (by mouth), rectal, intravenous (IV)
Drug classAnalgesics and antipyretics
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability63–89%[4]:73
Protein bindingnegligible to 10–25% in overdose[5]
MetabolismPredominantly in the liver[6]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, AM404, NAPQI[7]
Onset of actionPain relief onset by route:
oral – 37 minutes[8]
Intravenous – 8 minutes[8]
Elimination half-life1.9–2.5 hours[5]
ExcretionUrine[5]
Identifiers
  • N-(4-hydroxyphenyl)acetamide
CAS Number
PubChem CID
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC8H9NO2
Molar mass151.17 g·mol−1
3D model (JSmol)
Density1.263 g/cm3
Melting point169 °C (336 °F) [9][10]
Solubility in water
  • 7.21 g/kg (0 °C)[11]
  • 8.21 g/kg (5 °C)[11]
  • 9.44 g/kg (10 °C)[11]
  • 10.97 g/kg (15 °C)[11]
  • 12.78 g/kg (20 °C)[11]
  • ~14 mg/ml (20 °C)
  • CC(=O)Nc1ccc(O)cc1
  • InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) YesY
  • Key:RZVAJINKPMORJF-UHFFFAOYSA-N YesY
  (verify)
Paracetamol
Clinical data
PronunciationParacetamol: /ˌpærəˈsiːtəmɒl/
Acetaminophen: අසන්නi/əˌsiːtəˈmɪnəfɪn/
Trade namesTylenol, Panadol, others[1]
Other namesN-acetyl-para-aminophenol (APAP), acetaminophen (USAN US)
AHFS/Drugs.comMonograph
MedlinePlusa681004
License data
Pregnancy
category
Routes of
administration		Oral (by mouth), rectal, intravenous (IV)
Drug classAnalgesics and antipyretics
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability63–89%[4]:73
Protein bindingnegligible to 10–25% in overdose[5]
MetabolismPredominantly in the liver[6]
MetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, AM404, NAPQI[7]
Onset of actionPain relief onset by route:
oral – 37 minutes[8]
Intravenous – 8 minutes[8]
Elimination half-life1.9–2.5 hours[5]
ExcretionUrine[5]
Identifiers
  • N-(4-hydroxyphenyl)acetamide
CAS Number
PubChem CID
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC8H9NO2
Molar mass151.17 g·mol−1
3D model (JSmol)
Density1.263 g/cm3
Melting point169 °C (336 °F) [9][10]
Solubility in water
  • 7.21 g/kg (0 °C)[11]
  • 8.21 g/kg (5 °C)[11]
  • 9.44 g/kg (10 °C)[11]
  • 10.97 g/kg (15 °C)[11]
  • 12.78 g/kg (20 °C)[11]
  • ~14 mg/ml (20 °C)
  • CC(=O)Nc1ccc(O)cc1
  • InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) YesY
  • Key:RZVAJINKPMORJF-UHFFFAOYSA-N YesY
  (verify)

References

  1. ^ International Drug Names
  2. ^ "Acetaminophen Use During Pregnancy". Drugs.com. 14 June 2019. 9 March 2020 දින පැවති මුල් පිටපත වෙතින් සංරක්ෂිත පිටපත. සම්ප්‍රවේශය 25 February 2020.
  3. ^ "Regulatory Decision Summary – Acetaminophen Injection". Health Canada. 23 October 2014. 7 June 2022 දින පැවති මුල් පිටපත වෙතින් සංරක්ෂිත පිටපත. සම්ප්‍රවේශය 7 June 2022.
  4. ^ Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine (2015). Schug SA, Palmer GM, Scott DA, Halliwell R, Trinca J (eds.). Acute Pain Management: Scientific Evidence (4th ed.). Melbourne: Australian and New Zealand College of Anaesthetists (ANZCA), Faculty of Pain Medicine (FPM). ISBN 978-0-9873236-7-5. 31 July 2019 දින මුල් පිටපත (PDF) වෙතින් සංරක්ෂණය කරන ලදී. සම්ප්‍රවේශය 28 October 2019.
  5. ^ a b c Forrest JA, Clements JA, Prescott LF (1982). "Clinical pharmacokinetics of paracetamol". Clin Pharmacokinet. 7 (2): 93–107. doi:10.2165/00003088-198207020-00001. PMID 7039926. S2CID 20946160.
  6. ^ "Codapane Forte Paracetamol and codeine phosphate product information" (PDF). TGA eBusiness Services. Alphapharm Pty Limited. 29 April 2013. 6 February 2016 දින පැවති මුල් පිටපත වෙතින් සංරක්ෂිත පිටපත. සම්ප්‍රවේශය 10 May 2014.
  7. ^ "Acetaminophen Pathway (therapeutic doses), Pharmacokinetics". 4 March 2016 දින මුල් පිටපත වෙතින් සංරක්ෂණය කරන ලදී. සම්ප්‍රවේශය 13 January 2016.
  8. ^ a b Pickering G, Macian N, Libert F, Cardot JM, Coissard S, Perovitch P, Maury M, Dubray C (September 2014). "Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers". Drug Design, Development and Therapy. 8: 1621–1627. doi:10.2147/DDDT.S63476. PMC 4189711. PMID 25302017. In postoperative conditions for acute pain of mild to moderate intensity, the quickest reported time to onset of analgesia with APAP is 8 minutes9 for the iv route and 37 minutes6 for the oral route.
  9. ^ Karthikeyan M, Glen RC, Bender A (2005). "General Melting Point Prediction Based on a Diverse Compound Data Set and Artificial Neural Networks". Journal of Chemical Information and Modeling. 45 (3): 581–590. doi:10.1021/ci0500132. PMID 15921448.
  10. ^ "melting point data for paracetamol". Lxsrv7.oru.edu. 30 June 2012 දින මුල් පිටපත වෙතින් සංරක්ෂණය කරන ලදී. සම්ප්‍රවේශය 19 March 2011.
  11. ^ a b c d e Granberg RA, Rasmuson AC (1999). "Solubility of paracetamol in pure solvents". Journal of Chemical & Engineering Data. 44 (6): 1391–95. doi:10.1021/je990124v.

Brincidofovir

සංස්කරණය
Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Brincidofovir
Clinical data
Trade namesTembexa
Other namesCMX001; Cidofovir-HDP; hexadecyloxypropyl-cidofovir
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
  • ({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)[3-(hexadecyloxy)propoxy]phosphinic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC27H52N3O7P
Molar mass561.70 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCCCCCCOCCCOP(=O)(O)CO[C@H](CO)Cn1ccc(N)nc1=O
  • InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)/t25-/m0/s1
  • Key:WXJFKKQWPMNTIM-VWLOTQADSA-N
Brincidofovir
Clinical data
Trade namesTembexa
Other namesCMX001; Cidofovir-HDP; hexadecyloxypropyl-cidofovir
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
  • ({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)[3-(hexadecyloxy)propoxy]phosphinic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC27H52N3O7P
Molar mass561.70 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCCCCCCOCCCOP(=O)(O)CO[C@H](CO)Cn1ccc(N)nc1=O
  • InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)/t25-/m0/s1
  • Key:WXJFKKQWPMNTIM-VWLOTQADSA-N

References

  1. ^ "FDA approves drug to treat smallpox". U.S. Food and Drug Administration (FDA). 4 June 2021. 8 June 2021 දින පැවති මුල් පිටපත වෙතින් සංරක්ෂිත පිටපත. සම්ප්‍රවේශය 7 June 2021. මෙම ලිපිය තුළ මෙම ප්‍රභවයේ පෙළ ඇතුළත් වන අතර එය පොදු වසම තුළ පවතියි.

Albendazole

සංස්කරණය
Side by side comparison
{{Infobox drug}}{{Infobox drug/sandbox}}
Albendazole
Clinical data
Trade namesAlbenza, Valbazen, Zentel, others
AHFS/Drugs.comMonograph
MedlinePlusa610019
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only (for humans; veterinary suspension and paste are both OTC)[1]
Pharmacokinetic data
Bioavailability<5%[2]
Protein binding70%[2]
MetabolismHepatic[2]
Elimination half-life8-12 hours[2]
ExcretionBile (humans)
Urine (ruminants)
Identifiers
  • Methyl [5-(propylthio)-1H-benzoimidazol-2-yl]carbamate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
Chemical and physical data
FormulaC12H15N3O2S
Molar mass265.33 g·mol−1
3D model (JSmol)
Melting point208 to 210 °C (406 to 410 °F)
  • CCCSc2ccc1nc(NC(=O)OC)[nH]c1c2
  • InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) YesY
  • Key:HXHWSAZORRCQMX-UHFFFAOYSA-N YesY
  (verify)
Albendazole
Clinical data
Trade namesAlbenza, Valbazen, Zentel, others
AHFS/Drugs.comMonograph
MedlinePlusa610019
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only (for humans; veterinary suspension and paste are both OTC)[1]
Pharmacokinetic data
Bioavailability<5%[2]
Protein binding70%[2]
MetabolismHepatic[2]
Elimination half-life8-12 hours[2]
ExcretionBile (humans)
Urine (ruminants)
Identifiers
  • Methyl [5-(propylthio)-1H-benzoimidazol-2-yl]carbamate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
Chemical and physical data
FormulaC12H15N3O2S
Molar mass265.33 g·mol−1
3D model (JSmol)
Melting point208 to 210 °C (406 to 410 °F)
  • CCCSc2ccc1nc(NC(=O)OC)[nH]c1c2
  • InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) YesY
  • Key:HXHWSAZORRCQMX-UHFFFAOYSA-N YesY
  (verify)

References

  1. ^ Plumb DC (2011). "Albendazole". Plumb's Veterinary Drug Handbook (7th ed.). Stockholm, Wisconsin; Ames, Iowa: Wiley. pp. 19–21. ISBN 978-0-470-95964-0.
  2. ^ a b c d "Albenza, (albendazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. March 1, 2014 දින පැවති මුල් පිටපත වෙතින් සංරක්ෂිත පිටපත. සම්ප්‍රවේශය February 25, 2014.
"https://si.wikipedia.org/w/index.php?title=සැකිල්ල:Infobox_drug/testcases-warning&oldid=682087" වෙතින් සම්ප්‍රවේශනය කෙරිණි