"කොලෙස්ටරෝල්" හි සංශෝධන අතර වෙනස්කම්

== Clinical significance ==

=== Hypercholesterolemia ===

 

According to the [[lipid hypothesis]], abnormally high cholesterol levels ([[hypercholesterolemia]]), or, more correctly, higher concentrations of LDL and lower concentrations of functional HDL are strongly associated with [[cardiovascular disease]] because these promote [[atheroma]] development in arteries ([[atherosclerosis]]). This disease process leads to [[myocardial infarction]] (heart attack), [[stroke]] and [[peripheral vascular disease]]. Since higher blood LDL, especially higher LDL particle concentrations and smaller LDL particle size, contribute to this process more than the cholesterol content of the LDL particles,<ref name=Brun>{{cite journal |author=Brunzell JD ''et al'' |title=Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation – Lipoprotein management in patients with cardiometabolic risk |journal=Diabetes Care | volume=31| number=4| pages=811–822| month=April| year=2008| pmid=18375431 |url=http://care.diabetesjournals.org/cgi/reprint/31/4/811 |doi=10.2337/dc08-9018}}</ref> LDL particles are often termed "bad cholesterol" because they have been linked to atheroma formation. On the other hand, high concentrations of functional HDL, which can remove cholesterol from cells and atheroma, offer protection and are sometimes referred to colloquially as "good cholesterol". These balances are mostly genetically determined but can be changed by body build, [[medication]]s, food choices and other factors.<ref name="pmid12957096">{{cite journal |author=Durrington P |title=Dyslipidaemia |journal=Lancet |volume=362 |issue=9385 |pages=717–31 |year=2003 |pmid=12957096 |doi=10.1016/S0140-6736(03)14234-1}}</ref>